"The new Uppercut 22 WMR from CCI Ammunition offers self-defenders even more rimfire options. The new round features a 40-grain jacketed hollow-point bullet (JHP) with nose skiving, which initiates full and reliable expansion across all platforms..."

I've studied defense ballistics for thirty years or more.  I don't mean to be critical of CCI--the company is clearly responding to a perceived consumer desire as well, of course, as a financial profit.  I would not, however, ever carry .22 Magnum for self-defense, nor would I be likely to ever recommend it: